Use of the lymphocyte cytokinesis-block micronucleus assay in occupational biomonitoring of genome damage caused by in vivo exposure to chemical genotoxins …

A Nersesyan, M Fenech, C Bolognesi, M Mišík… - … Research/Reviews in …, 2016 - Elsevier
This article concerns the use of the lymphocyte cytokinesis-block micronucleus (CBMN)
assay in biomonitoring of occupational and environmental exposures to genotoxic agents …

Challenges in risk assessment of multiple mycotoxins in food

R Assunção, MJ Silva, P Alvito - World Mycotoxin …, 2016 - wageningenacademic.com
Most fungi are able to produce several mycotoxins simultaneously and, consequently, to
contaminate a wide variety of foodstuffs. Therefore, the risk of human co-exposure to …

[图书][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …

[HTML][HTML] Mixture effects in samples of multiple contaminants–An inter-laboratory study with manifold bioassays

R Altenburger, M Scholze, W Busch, BI Escher… - Environment …, 2018 - Elsevier
Chemicals in the environment occur in mixtures rather than as individual entities.
Environmental quality monitoring thus faces the challenge to comprehensively assess a …

[HTML][HTML] Polystyrene microplastic particles in combination with pesticides and antiviral drugs: Toxicity and genotoxicity in Ceriodaphnia dubia

R Nugnes, C Russo, M Lavorgna, E Orlo, M Kundi… - Environmental …, 2022 - Elsevier
Freshwater ecosystems are recognized as non-negligible sources of plastic contamination
for the marine environment that is the final acceptor of 53 thousand tons of plastic per year …

[HTML][HTML] From single chemicals to mixtures—Reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

TJ Runnalls, N Beresford, S Kugathas… - Aquatic Toxicology, 2015 - Elsevier
The aquatic environment is polluted with thousands of chemicals. It is currently unclear
which of these pose a significant threat to aquatic biota. The typical exposure scenario is …

[HTML][HTML] Should the scope of human mixture risk assessment span legislative/regulatory silos for chemicals?

RM Evans, OV Martin, M Faust… - Science of the Total …, 2016 - Elsevier
Current chemicals regulation operates almost exclusively on a chemical-by-chemical basis,
however there is concern that this approach may not be sufficiently protective if two or more …

Genotoxicity and cytotoxicity of chromium, copper, manganese and lead, and their mixture in WIL2-NS human B lymphoblastoid cells is enhanced by folate depletion

CG Alimba, V Dhillon, AA Bakare, M Fenech - Mutation Research/Genetic …, 2016 - Elsevier
Heavy metal exposure or dietary deficiency is associated with increased genetic damage,
cancer and age-related diseases. Folate (vitamin B9) required for DNA repair and synthesis …

Flubendazole enhances the inhibitory effect of paclitaxel via HIF1α/PI3K/AKT signaling pathways in breast cancer

Y Zhou, M Liao, Z Li, J Ye, L Wu, Y Mou, L Fu… - International Journal of …, 2023 - mdpi.com
Paclitaxel, a natural anticancer drug, is widely recognized and extensively utilized in the
treatment of breast cancer (BC). However, it may lead to certain side effects or drug …

[HTML][HTML] Distinctions between similarly and dissimilarly-acting mixture components unnecessarily complicate mixture risk assessments–implications for assessing low …

A Kortenkamp - Current Opinion in Toxicology, 2023 - Elsevier
Distinguishing between mixtures of substances with similar and dissimilar modes of action is
believed to have implications for judgements whether mixture risks might arise when all …