Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
[HTML][HTML] Nrf2-Keap1 signaling in oxidative and reductive stress
I Bellezza, I Giambanco, A Minelli, R Donato - Biochimica et Biophysica …, 2018 - Elsevier
Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …
Autophagy as a promoter of longevity: insights from model organisms
Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …
[HTML][HTML] DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass
G Favaro, V Romanello, T Varanita… - Nature …, 2019 - nature.com
Mitochondrial quality control is essential in highly structured cells such as neurons and
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …
[PDF][PDF] Age-associated loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence
C Tezze, V Romanello, MA Desbats, GP Fadini… - Cell metabolism, 2017 - cell.com
Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …
unknown. Here, we find that sedentary but not active humans display an age-related decline …
[HTML][HTML] The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass
V Romanello, M Sandri - Cellular and Molecular Life Sciences, 2021 - Springer
The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …
[HTML][HTML] Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy
G Milan, V Romanello, F Pescatore, A Armani… - Nature …, 2015 - nature.com
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …
[HTML][HTML] The rise of mitochondria in medicine
Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …
perform multiple essential functions beyond energy production, impacting most areas of cell …
Mitochondrial fission, fusion, and stress
RJ Youle, AM Van Der Bliek - Science, 2012 - science.org
Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria
when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by …
when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …