Recognition in the domain of molecular chirality: from noncovalent interactions to separation of enantiomers

P Peluso, B Chankvetadze - Chemical Reviews, 2022 - ACS Publications
It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in
nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules …

Cyclodextrin-based ocular drug delivery systems: A comprehensive review

Q Wang, A Zhang, L Zhu, X Yang, G Fang… - Coordination Chemistry …, 2023 - Elsevier
Cyclodextrin (CD), a class of cyclic oligosaccharides with an external hydrophilic surface
and a central hydrophobic cavity is recognized as a promising pharmaceutical excipient due …

Pharmaceutical applications of cyclodextrins: basic science and product development

T Loftsson, ME Brewster - Journal of pharmacy and …, 2010 - academic.oup.com
Objectives Drug pipelines are becoming increasingly difficult to formulate. This is punctuated
by both retrospective and prospective analyses that show that while 40% of currently …

Cyclodextrins as pharmaceutical solubilizers

ME Brewster, T Loftsson - Advanced drug delivery reviews, 2007 - Elsevier
Cyclodextrins are useful functional excipients that have enjoyed widespread attention and
use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these …

Cyclodextrins and their pharmaceutical applications

T Loftsson, D Duchene - International journal of pharmaceutics, 2007 - Elsevier
Cyclodextrins were first described by Villiers in 1891. Schardinger laid the foundation of the
cyclodextrin chemistry in 1903–1911 and identified both α-and β-cyclodextrin. In the 1930s …

Self-association of cyclodextrins and cyclodextrin complexes

T Loftsson, M Másson, ME Brewster - Journal of pharmaceutical sciences, 2004 - Elsevier
Cyclodextrins are useful functional excipients, which are being used in an ever-increasing
way to camouflage undesirable pharmaceutical characteristics, especially poor aqueous …

Self-assembled cyclodextrin aggregates and nanoparticles

M Messner, SV Kurkov, P Jansook… - International journal of …, 2010 - Elsevier
Cyclodextrins (CDs) are widely used as enabling pharmaceutical excipients, mainly as
solubilizing complexing agents. CDs are cyclic oligosaccharides with hydrophilic outer …

Self-assembly of cyclodextrins and their complexes in aqueous solutions

A Ryzhakov, T Do Thi, J Stappaerts, L Bertoletti… - Journal of …, 2016 - Elsevier
Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous
pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are …

The complexation efficiency

T Loftsson, D Hreinsdóttir, M Másson - Journal of Inclusion Phenomena …, 2007 - Springer
Studies have shown that cyclodextrins form both inclusion and non-inclusion complexes and
that several different types of complexes can coexist in aqueous solutions. In addition, both …

Pharmaceutical applications of cyclodextrins and their derivatives

P Dhiman, M Bhatia - Journal of Inclusion Phenomena and Macrocyclic …, 2020 - Springer
Cyclodextrins (CDs) are abundantly explored in the field of medicines for the design of
various types of drug delivery systems. They are cyclic oligosaccharides carrying α (1, 4) …