New psychoactive substances represent a public health threat since they are not controlled
by international conventions, are easily accessible online and are sold as a legal alternative …

The synthetic cathinones are derived from the naturally occurring drug cathinone found in
the khat plant (Catha edulis) and have chemical structures and neurochemical …

α-Amino ketone moieties are present in many pharmacologically active molecules, but their
synthesis is challenging. Herein, we report a mild, operationally simple method for direct …

Due to the importance of the amino ketone motif in synthetic and medicinal chemistry, the
number of protocols developed in recent years has considerably increased. This review …

Synthetic cathinones are derivatives of the naturally occurring compound cathinone, the
main psychoactive ingredient in the khat plant Catha edulis. Cathinone is the β-keto analog …

A new approach to the enantiocontrolled synthesis of α‐amino ketone derivatives is
disclosed by employing a decarboxylative acylation strategy. Thus, when an acyl chloride …

Synthetic cathinones are common constituents of abused “bath salts” preparations and
represent a large family of structurally related compounds that function as cocaine-like …

The use of new psychoactive substances (NPS) is increasing and currently> 600 NPS have
been reported. However, limited information on neuropharmacological and toxicological …

Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for
the treatment of specific neuropsychiatric disorders. However, they can also produce severe …

In the present work an isocratic enantioselective high-performance liquid chromatography-
tandem mass spectrometry (LC-MS/MS) method was developed for the separation and …