Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

Oligodendrocytes are specialized cells that insulate and support axons with their myelin
membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as …

Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …

Background The brain is a highly mechanosensitive organ, and changes in the mechanical
properties of brain tissue influence many physiological and pathological processes. Piezo …

Medulloblastoma is one of the most common malignant pediatric brain tumors derived from
posterior fossa. The current treatment includes maximal safe surgical resection …

The site-specific delivery of drugs, especially anti-cancer drugs has been an interesting field
for researchers and the reason is low accumulation of cytotoxic drugs in cancer cells …

Ion channels, transporters, and other ion-flux controlling proteins, collectively comprising the
“ion permeome”, are common drug targets, however, their roles in cancer remain …

In this issue, Chen et al. 1 show that genetic knockout of Piezo2 in SOX2+ medulloblastoma
cells decreased local tissue stiffness, increased drug delivery across the blood-tumor …

The pursuit of effective treatments for brain tumors has increasingly focused on the
promising area of nanoparticle-enhanced radiotherapy (NERT). This review elucidates the …