An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

A riboswitch is a non-protein coding sequence capable of directly binding a small molecule
effector without the assistance of accessory proteins to regulate expression of the mRNA in …

It has been almost 30 years since the invention of Systematic Evolution of Ligands by
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …

Oligonucleotide receptors (aptamers), which change conformation upon target recognition,
enable electronic biosensing under high ionic-strength conditions when coupled to field …

Bacterial riboswitches couple small-molecule ligand binding to RNA conformational
changes that widely regulate gene expression, rendering them potential targets for antibiotic …

The rapid and cost-effective detection of bacteria is of great importance to ensuring food
safety, preventing food poisoning. Herein, we developed a sensitive detection of Escherichia …

The detection of Salmonella enterica serovar Typhimurium (S. Typhimurium) is very
important for the prevention of food poisoning and other infectious diseases. Here we …

RNA molecules can act as potential drug targets in different diseases, as their dysregulated
expression or misfolding can alter various cellular processes. Noncoding RNAs account …

Highlights•Riboswitches exhibit multiple conformations in the absence of cognate
ligand.•Multi-conformational state mechanisms fine-tune gene-regulation.•Conformational …

Riboswitches are RNA sequences that regulate gene expression by undergoing structural
changes upon the specific binding of cellular metabolites. Crystal structures of purine …