Modulators of microglial activation and polarization after intracerebral haemorrhage
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
F Alyu, M Dikmen - Acta neuropsychiatrica, 2017 - cambridge.org
ObjectiveEpilepsy is a chronic neurological disease characterised with seizures. The
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
aetiology of the most generalised epilepsies cannot be explicitly determined and the …
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy
Progressive myoclonus epilepsies (PMEs) are a group of rare, inherited disorders
manifesting with action myoclonus, tonic-clonic seizures and ataxia. We sequenced the …
manifesting with action myoclonus, tonic-clonic seizures and ataxia. We sequenced the …
Innate immune response in brain, NF-kappa B signaling and cystatins
N Kopitar-Jerala - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Recently several reports have demonstrated that innate immune response and inflammation
have an important role in major neurodegenerative diseases. The activation of the NF-κB …
have an important role in major neurodegenerative diseases. The activation of the NF-κB …
Neuroinflammation in post-traumatic epilepsy: pathophysiology and tractable therapeutic targets
Epilepsy is a common chronic consequence of traumatic brain injury (TBI), contributing to
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …
increased morbidity and mortality for survivors. As post-traumatic epilepsy (PTE) is drug …
Mechanism and regulation of microglia polarization in intracerebral hemorrhage
Y Guo, W Dai, Y Zheng, W Qiao, W Chen, L Peng… - Molecules, 2022 - mdpi.com
Intracerebral hemorrhage (ICH) is the most lethal subtype of stroke, but effective treatments
are lacking, and neuroinflammation plays a key role in the pathogenesis. In the innate …
are lacking, and neuroinflammation plays a key role in the pathogenesis. In the innate …
[HTML][HTML] Microglia as therapeutic target in central nervous system disorders
O Fatoba, T Itokazu, T Yamashita - Journal of Pharmacological Sciences, 2020 - Elsevier
Chronic microglial activation is associated with the pathogenesis of several CNS disorders.
Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus …
Microglia show phenotypic diversity and functional complexity in diseased CNS. Thus …
Reactive glia-derived neuroinflammation: a novel hallmark in Lafora progressive myoclonus epilepsy that progresses with age
M Lahuerta, D Gonzalez, C Aguado… - Molecular …, 2020 - Springer
Lafora disease (LD) is a rare, fatal form of progressive myoclonus epilepsy. The molecular
basis of this devastating disease is still poorly understood, and no treatment is available yet …
basis of this devastating disease is still poorly understood, and no treatment is available yet …
[HTML][HTML] Inhibition of MyD88 signaling skews microglia/macrophage polarization and attenuates neuronal apoptosis in the hippocampus after status epilepticus in mice
JT Liu, SX Wu, H Zhang, F Kuang - Neurotherapeutics, 2018 - Elsevier
Inflammation is implicated in epileptogenesis. Activated microglia and macrophages
(MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal …
(MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal …
Neurodegenerative pathways as targets for acquired epilepsy therapy development
There is a growing body of clinical and experimental evidence that neurodegenerative
diseases and epileptogenesis after an acquired brain insult may share common etiological …
diseases and epileptogenesis after an acquired brain insult may share common etiological …