Mesenchymal stem/stromal cells in cancer therapy
T Lan, M Luo, X Wei - Journal of Hematology & Oncology, 2021 - Springer
The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone
marrow in 1976, have been identified in nearly all tissues of human body now. The …
marrow in 1976, have been identified in nearly all tissues of human body now. The …
Selective JAKinibs: prospects in inflammatory and autoimmune diseases
AT Virtanen, T Haikarainen, J Raivola, O Silvennoinen - BioDrugs, 2019 - Springer
Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …
and Activators of Transcription) pathway, play a central role in the pathogenesis of …
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
TL Song, ML Nairismägi, Y Laurensia… - Blood, The Journal …, 2018 - ashpublications.org
Mature T-cell lymphomas, including peripheral T-cell lymphoma (PTCL) and extranodal
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …
NK/T-cell lymphoma (NKTL), represent a heterogeneous group of non-Hodgkin lymphomas …
Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
B Groner, V von Manstein - Molecular and cellular endocrinology, 2017 - Elsevier
Abstract The effects of Jak Stat signaling and the persistent activation of Stat3 and Stat5 on
tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite …
tumor cell survival, proliferation and invasion have made the Jak Stat pathway a favorite …
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
L Jiang, ZH Gu, ZX Yan, X Zhao, YY Xie, ZG Zhang… - Nature …, 2015 - nature.com
Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56+ and cytoCD3+
lymphocytes with aggressive clinical course, which is prevalent in Asian and South …
lymphocytes with aggressive clinical course, which is prevalent in Asian and South …
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …
Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia
The comprehensive genetic alterations underlying the pathogenesis of T-cell prolymphocytic
leukemia (T-PLL) are unknown. To address this, we performed whole-genome sequencing …
leukemia (T-PLL) are unknown. To address this, we performed whole-genome sequencing …
Advances in targeted therapy for malignant lymphoma
L Wang, W Qin, YJ Huo, X Li, Q Shi… - Signal transduction and …, 2020 - nature.com
The incidence of lymphoma has gradually increased over previous decades, and it ranks
among the ten most prevalent cancers worldwide. With the development of targeted …
among the ten most prevalent cancers worldwide. With the development of targeted …
Disorders of the JAK/STAT pathway in T cell lymphoma pathogenesis: implications for immunotherapy
TA Waldmann, J Chen - Annual review of immunology, 2017 - annualreviews.org
Common gamma receptor–dependent cytokines and their JAK/STAT pathways play pivotal
roles in T cell immunity. Abnormal activation of this system was pervasive in diverse T cell …
roles in T cell immunity. Abnormal activation of this system was pervasive in diverse T cell …
Role of non receptor tyrosine kinases in hematological malignances and its targeting by natural products
Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …