Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …

Schizophrenia (SZ) and bipolar disorder (BD) are debilitating neurobehavioural disorders
likely influenced by genetic and non-genetic factors and which can be seen as complex …

Attention‐deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study
aimed to discover common and rare DNA variants associated with ADHD in a large …

Metabotropic glutamate receptor 7 (mGlu7) has been suggested to be a promising novel
target for treatment of a range of disorders, including anxiety, post-traumatic stress disorder …

Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant
glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7), a receptor …

Understanding the complex interaction between stress and genetics that leads to the
manifestation of disorders such as depression, anxiety, and cognitive dysfunction is one of …

The metabotropic glutamate receptor 7 (mGlu 7), encoded by the GRM7 gene in humans, is
a presynaptic, G protein-coupled glutamate receptor that is essential for modulating …

Herein, we report on the further chemical optimization of the first reported mGlu 7 positive
allosteric modulator (PAM), VU6027459. Replacement of the quinoline core by a cinnoline …

Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors
(mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly expressed in …

The search for biomarkers of response to antipsychotic medications is hindered by
difficulties inherent in the topic or related to persistent methodological difficulties, such as …