An increasing recognition that brain and body are dynamically coupled has enriched our
scientific understanding of mental health conditions. Peripheral signals interact centrally to …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Importance Observational studies have reported associations between antihypertensive
medication and psychiatric disorders, although the reported direction of association appears …

RNA splicing is a key mechanism linking genetic variation with psychiatric disorders.
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …

Depression in dementia is common, disabling and causes significant distress to patients and
carers. Despite widespread use of antidepressants for depression in dementia, there is no …

CNS disorders, and in particular psychiatric illnesses, lack definitive disease-altering
therapeutics. The limited understanding of the mechanisms driving these illnesses with the …

Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain.
Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects …

A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

Background Statins have shown both protective and adverse associations with
neuropsychiatric outcomes. We aimed to examine the possible associations between statins …

Background Young people with psychosis are at high risk of developing cardiometabolic
disorders; however, there is no suitable cardiometabolic risk prediction algorithm for this …