The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …

Endothelial cells (EC) play a key role in atherosclerosis. Although EC are in constant contact
with low density lipoproteins (LDL), how EC process LDL and whether this influences …

Background Endothelial cell-cell junctions maintain endothelial integrity and regulate
vascular morphogenesis and homeostasis. Cell-cell junctions are usually depicted with a …

In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …

Neutrophil extravasation and the regulation of vascular permeability require dynamic actin
rearrangements in the endothelium. In this study, we analyzed in vivo whether these …