Mind the gap: mechanisms regulating the endothelial barrier
MY Radeva, J Waschke - Acta physiologica, 2018 - Wiley Online Library
The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
E Khatib-Massalha, S Bhattacharya… - Nature …, 2020 - nature.com
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …
Role of GTPases in control of microvascular permeability
V Spindler, N Schlegel, J Waschke - Cardiovascular research, 2010 - academic.oup.com
Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …
gaps between endothelial cells of post-capillary venules. Under these conditions …
Epac: defining a new mechanism for cAMP action
M Gloerich, JL Bos - Annual review of pharmacology and …, 2010 - annualreviews.org
cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …
biological processes. The discovery of the cAMP target Epac explained various effects of …
Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
Endothelial cells (EC) play a key role in atherosclerosis. Although EC are in constant contact
with low density lipoproteins (LDL), how EC process LDL and whether this influences …
with low density lipoproteins (LDL), how EC process LDL and whether this influences …
Adherens junctions connect stress fibres between adjacent endothelial cells
Background Endothelial cell-cell junctions maintain endothelial integrity and regulate
vascular morphogenesis and homeostasis. Cell-cell junctions are usually depicted with a …
vascular morphogenesis and homeostasis. Cell-cell junctions are usually depicted with a …
Driving Rho GTPase activity in endothelial cells regulates barrier integrity
CML Beckers, VWM van Hinsbergh… - Thrombosis and …, 2010 - thieme-connect.com
In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42
has been developed from regulatory proteins that regulate specific actin cytoskeletal …
has been developed from regulatory proteins that regulate specific actin cytoskeletal …
Dynamic regulation of vascular permeability by vascular endothelial cadherin-mediated endothelial cell-cell junctions
SS Rho, K Ando, S Fukuhara - Journal of Nippon Medical School, 2017 - jstage.jst.go.jp
Endothelial cells lining blood vessels regulate vascular barrier function, which controls the
passage of plasma proteins and circulating cells across the endothelium. In most normal …
passage of plasma proteins and circulating cells across the endothelium. In most normal …
[HTML][HTML] Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo
M Schnoor, FPL Lai, A Zarbock, R Kläver… - The Journal of …, 2011 - ncbi.nlm.nih.gov
Neutrophil extravasation and the regulation of vascular permeability require dynamic actin
rearrangements in the endothelium. In this study, we analyzed in vivo whether these …
rearrangements in the endothelium. In this study, we analyzed in vivo whether these …