Cerebellar modules and their role as operational cerebellar processing units

R Apps, R Hawkes, S Aoki, F Bengtsson, AM Brown… - The Cerebellum, 2018 - Springer
The compartmentalization of the cerebellum into modules is often used to discuss its
function. What, exactly, can be considered a module, how do they operate, can they be …

Cerebellum lecture: the cerebellar nuclei—core of the cerebellum

JM Kebschull, F Casoni, GG Consalez, D Goldowitz… - The Cerebellum, 2024 - Springer
The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum …

Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei

AL Person, IM Raman - Nature, 2012 - nature.com
An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release
GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive …

Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions

W Heffley, EY Song, Z Xu, BN Taylor, MA Hughes… - Nature …, 2018 - nature.com
The prevailing model of cerebellar learning states that climbing fibers (CFs) are both driven
by, and serve to correct, erroneous motor output. However, this model is grounded largely in …

[PDF][PDF] Excitatory cerebellar nucleocortical circuit provides internal amplification during associative conditioning

Z Gao, M Proietti-Onori, Z Lin, MM Ten Brinke… - Neuron, 2016 - cell.com
Closed-loop circuitries between cortical and subcortical regions can facilitate precision of
output patterns, but the role of such networks in the cerebellum remains to be elucidated …

Synchronous spiking of cerebellar Purkinje cells during control of movements

E Sedaghat-Nejad, JS Pi, P Hage… - Proceedings of the …, 2022 - National Acad Sciences
The ability of the brain to accurately control a movement depends on the cerebellum. Yet,
how the cerebellar neurons encode information relevant for this control remains poorly …

Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice

MM Ten Brinke, SA Heiney, X Wang, M Proietti-Onori… - Elife, 2017 - elifesciences.org
While research on the cerebellar cortex is crystallizing our understanding of its function in
learning behavior, many questions surrounding its downstream targets remain. Here, we …

[HTML][HTML] Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation

L Witter, CB Canto, TM Hoogland… - Frontiers in neural …, 2013 - frontiersin.org
The cerebellum refines the accuracy and timing of motor performance. How it encodes
information to perform these functions is a major topic of interest. We performed whole cell …

Manual muscle testing—force profiles and their reproducibility

FN Bittmann, S Dech, M Aehle, LV Schaefer - Diagnostics, 2020 - mdpi.com
The manual muscle test (MMT) is a flexible diagnostic tool, which is used in many
disciplines, applied in several ways. The main problem is the subjectivity of the test. The …

[HTML][HTML] Synchrony and neural coding in cerebellar circuits

AL Person, IM Raman - Frontiers in neural circuits, 2012 - frontiersin.org
The cerebellum regulates complex movements and is also implicated in cognitive tasks, and
cerebellar dysfunction is consequently associated not only with movement disorders, but …