Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …

The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the
capacity to suppress adaptive immune responses during cancer. It remains elusive how …

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD)
and identification of potential therapeutic targets by mediating podocyte lipid metabolism …

Intercellular adhesion molecule-1 (ICAM-1) is up-regulated during inflammation by several
cell types. ICAM-1 is best known for its role in mediating leukocyte adhesion to endothelial …

Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires
transendothelial migration (TEM). TEM involves several well-studied sequential adhesive …

The neutrophil, a short-lived effector leukocyte of the innate immune system best known for
its proteases and other degradative cargo, has unique, reciprocal physiological interactions …

Neutrophil (PMN) infiltration of the intestinal mucosa often leads to severe epithelial injury;
however, how this process occurs is unclear. This article describes a novel mechanism …

Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body
against external noxious substances and pathogens. At a molecular level, the mucosal …

Polymorphonuclear neutrophils (PMN s) are innate immune system cells that play an
essential role in eradicating invading pathogens. PMN migration to sites of …