Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

Abstract Calcium (Ca2+)-activated chloride channels are fundamental mediators in
numerous physiological processes including transepithelial secretion, cardiac and neuronal …

Calcium-dependent chloride channels are required for normal electrolyte and fluid
secretion, olfactory perception, and neuronal and smooth muscle excitability. The molecular …

Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction,
epithelial secretion, and smooth muscle contraction. Other crucial roles of CaCCs include …

Mutations in the gene BEST1 are causally associated with as many as five clinically distinct
retinal degenerative diseases, which are collectively referred to as the “bestrophinopathies” …

Addictive drugs increase ventral tegmental area (VTA) dopamine (DA) neuron activity
through distinct cellular mechanisms, one of which involves disinhibition of DA neurons by …