The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

More than 50 years ago, cells were observed to die during insect development via a process
that was named'programmed cell death'. Later, a similar cell death process was found to …

Background Varicocele (VC) is present in 35-40% of men with infertility. However, current
surgical and antioxidant treatments are not completely effective. In addition to oxidative …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory
signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory …

The mammalian testis possesses a special immunological environment because of its
properties of remarkable immune privilege and effective local innate immunity. Testicular …

To evaluate the utility of tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) as
a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) …

Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for
maintenance immunosuppression. We report a strategy through which cotransplantation of …

Using the cytoplasmic domain of Fas in the yeast twohybrid system, we have identified a
novel interacting protein, FADD, which binds Fasand Fas-FD5, a mutant of Fas possessing …

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to
the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE …