Triggers, cascades, and endpoints: connecting the dots of coral bleaching mechanisms

J Helgoe, SK Davy, VM Weis… - Biological …, 2024 - Wiley Online Library
The intracellular coral–dinoflagellate symbiosis is the engine that underpins the success of
coral reefs, one of the most diverse ecosystems on the planet. However, the breakdown of …

Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles

NJ MacKnight, BA Dimos, KM Beavers, EM Muller… - Science …, 2022 - science.org
Infectious diseases are an increasing threat to coral reefs, resulting in altered community
structure and hindering the functional contributions of disease-susceptible species. We …

Promoted “click” SERS detection for precise intracellular imaging of caspase-3

W Zhu, CY Wang, JM Hu, AG Shen - Analytical Chemistry, 2021 - ACS Publications
Although homogeneous detection of some biomolecules has been of great significance in
clinical assay, it faces great challenges in achieving precise in situ imaging of biomolecules …

Intrinsic apoptosis is evolutionarily divergent among metazoans

G Krasovec, HR Horkan, É Quéinnec… - Evolution …, 2024 - academic.oup.com
Apoptosis is regulated cell death that depends on caspases. A specific initiator caspase is
involved upstream of each apoptotic signaling pathway. Characterized in nematode, fly, and …

Highly sensitive and selective SERS detection of caspase-3 during cell apoptosis based on the target-induced hotspot effect

Y Zhuang, H Dong, T Liu, Y Zhao, Y Xu, X Zhao, D Sun - Analyst, 2024 - pubs.rsc.org
Caspase-3 is an important biomarker for the process of apoptosis, which is a key target for
cancer treatment. Due to its low concentration in single cells and the structural similarity of …

[HTML][HTML] Evolution of the folding landscape of effector caspases

S Shrestha, AC Clark - Journal of Biological Chemistry, 2021 - ASBMB
Caspases are a family of cysteinyl proteases that control programmed cell death and
maintain homeostasis in multicellular organisms. The caspase family is an excellent model …

Sequential unfolding mechanisms of monomeric caspases

I Joglekar, AC Clark - Biochemistry, 2023 - ACS Publications
Caspases are evolutionarily conserved cysteinyl proteases that are integral in cell
development and apoptosis. All apoptotic caspases evolved from a common ancestor into …

Cnidaria XIAP activates caspase-mediated cell death

Y Chen, M Wu, Z Yuan, Q Wang, H Xu, L Sun - bioRxiv, 2024 - biorxiv.org
In vertebrate, X-linked inhibitor of apoptosis (XIAP) is a potent inhibitor of apoptosis. XIAP
inhibits apoptosis by interacting with proapoptotic caspases via the baculovirus IAP repeat …

Molecular and environmental aspects of innate immune pattern recognition

AE Gauthier - 2022 - search.proquest.com
Since the publication of the Janeway's pattern recognition hypothesis in 1989, the past 33
years have seen rapid advances in the study of innate immunity, with a focus on pathogen …

[图书][B] The Mechanism of Enzyme Stability and Specificity in Caspase-3

L Yao - 2021 - search.proquest.com
The caspase family has been found as regulated proteins that play an important role in
apoptosis and inflammation. Incorrect caspase regulation may cause serious diseases such …