Background Anthracyclines are commonly used chemotherapeutic agents to treat malignant
tumors. However, cardiotoxicity is a potentially serious adverse effect of anthracyclines. Beta …

The rational choice theory is based on this idea that people rationally pursue goals for
increasing their personal interests. Here, we present a new concept of rational choice as a …

This paper is a review on the types of antagonists and the signaling mechanism pathways
that have been used to determine the mechanisms of action employed for vasodilation by …

Introduction Imeglimin, a glucose‐lowering agent targeting mitochondrial bioenergetics,
decreases reactive oxygen species (ROS) overproduction and improves glucose …

The mineralocorticoid receptor (MR) plays an important role in the development of chronic
kidney disease (CKD) and associated cardiovascular complications. Antagonizing the …

The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which
increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial …

Aim To determine whether non‐steroidal mineralocorticoid receptor (MR) antagonists
oppose metabolic syndrome‐related end‐organ, ie cardiac, damage. Materials and methods …

Aims Enhanced heart rate (HR) is a compensatory mechanism in chronic heart failure
(CHF), preserving cardiac output, but at the cost of increased left ventricular (LV) oxygen …

Angiotensin II contributes to myocardial tissue remodeling and interstitial fibrosis through
NADPH oxidase-mediated generation of oxidative stress in the progression of heart failure …

The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among
which is the vascular endothelial growth factor receptor type 2 (VEGFR2), a key component …