The blood–brain barrier (BBB) is formed by microvascular endothelial cells sealed by
tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated …

An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the
immune system and may result in chronic inflammation. The epithelial cells of the intestinal …

Emerging lines of research evidence point to a vital role of gut–kidney axis in the
development of hyperuricemia (HUA), which has been identified as an increasing burden …

Systemic inflammation, which results from the massive release of proinflammatory
molecules into the circulatory system, is a major risk factor for severe illness, but the precise …

Hepatic steatosis is characterized by triglyceride accumulation within hepatocytes in
response to a high calorie intake, and it may be related to intestinal microbiota disturbances …

Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for
many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis …

Nephrotoxicity is often underestimated because renal clearance in animals is higher
compared to in humans. This paper aims to illustrate the potential to fill in such …

A growing number of investigations report the association between gut permeability and
intestinal or extra-intestinal disorders under the basis that translocation of gut luminal …

The breakdown of the gut's mucosal barrier that prevents the infiltration of microorganisms,
inflammatory cytokines and toxins into bodily tissues can lead to inflammatory bowel …

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a multifactorial chronic
gastrointestinal disorder characterized by inflammation and immune response. In this …