Skeletal muscle and bone rely on a number of growth factors to undergo development,
modulate growth, and maintain physiological strength. A major player in these actions is …

Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

Calcium is vital for many physiological functions including bone mineralization. Postnatal
deposition of calcium into bone is greatest in infancy and continues through childhood and …

Patients with permanent hypoparathyroidism require lifelong replacement therapy to avoid
life-threatening complications, The benefits of conventional treatment are limited, however …

Roux‐en‐Y gastric bypass (RYGB) surgery is a highly effective treatment for obesity but
negatively affects the skeleton. Studies of skeletal effects have generally examined areal …

Results At enrollment, median age was 11 years [interquartile range (IQR), 8–15], GFR was
44 ml/min per 1.73 m 2 (IQR, 33–57), and FGF23 was 132 RU/ml (IQR, 88–200). During a …

Context Female-to-male ratio in primary hyperparathyroidism (PHPT) is 3: 1, but data on sex
impact on the clinical presentation are limited. Design We evaluated, retrospectively, sex …

Molecular mechanisms mediating tonic secretion of parathyroid hormone (PTH) in response
to hypocalcaemia and hyperparathyroidism (HPT) are unclear. Here we demonstrate …

Anabolic actions of PTH in bone involve increased deposition of mineralizing matrix.
Regulatory feedback of the process may be important to maintain calcium homeostasis and …

Heterozygous germline gain-of-function mutations of G-protein subunit α 11 (Gα 11), a
signaling partner for the calcium-sensing receptor (CaSR), result in autosomal dominant …