[HTML][HTML] Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

[HTML][HTML] Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: an overview

L Huang, C Wu, H Gao, C Xu, M Dai, L Huang, H Hao… - Antibiotics, 2022 - mdpi.com
Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

[HTML][HTML] Global spread of carbapenem-resistant Enterobacteriaceae: Epidemiological features, resistance mechanisms, detection and therapy

J Ma, X Song, M Li, Z Yu, W Cheng, Z Yu… - Microbiological …, 2023 - Elsevier
Bacterial drug resistance has become a global public health threat, among which the
infection of carbapenem-resistant Enterobacterales (CRE) is one of the top noticeable …

Challenges and opportunities in biological funneling of heterogeneous and toxic substrates beyond lignin

AJ Borchert, WR Henson, GT Beckham - Current opinion in biotechnology, 2022 - Elsevier
Significant developments in the understanding and manipulation of microbial metabolism
have enabled the use of engineered biological systems toward a more sustainable energy …

[HTML][HTML] “Superbugs” with hypervirulence and carbapenem resistance in Klebsiella pneumoniae: the rise of such emerging nosocomial pathogens in China

D Pu, J Zhao, K Chang, X Zhuo, B Cao - Science Bulletin, 2023 - Elsevier
Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

[HTML][HTML] Pharmaceutical approaches on antimicrobial resistance: prospects and challenges

F Nainu, AD Permana, NJN Djide, QK Anjani… - Antibiotics, 2021 - mdpi.com
The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has
become a significant public health problem globally. The management of this issue using …

[HTML][HTML] Biocidal resistance in clinically relevant microbial species: a major public health risk

E Meade, MA Slattery, M Garvey - Pathogens, 2021 - mdpi.com
Antimicrobial resistance is one of the greatest dangers to public health of the 21st century,
threatening the treatment and prevention of infectious diseases globally. Disinfection, the …

Expression of RND efflux pumps mediated antibiotic resistance in Pseudomonas aeruginosa clinical strains

M Rahbar, R Hamidi-Farahani, A Asgari… - Microbial …, 2021 - Elsevier
Abstract Resistance-Nodulation-Division (RND) efflux pumps are responsible for multidrug
resistance in Pseudomonas aeruginosa. The present study aimed to evaluate the …

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

G Kumar, AK Tudu - Bioorganic & Medicinal Chemistry, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a pathogen responsible for various community and
hospital-acquired infections with life-threatening complications like bacteraemia …

[HTML][HTML] Host-bacterial pathogen communication: the wily role of the multidrug efflux pumps of the MFS family

M Pasqua, MC Bonaccorsi di Patti, G Fanelli… - Frontiers in Molecular …, 2021 - frontiersin.org
Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to
the surroundings depends on their ability to sense environmental variations and to respond …