Over two decades after the introduction of cardiac resynchronization therapy (CRT) into
clinical practice,∼ 30% of candidates continue to fail to respond to this highly effective …

Chronic heart failure continues to impose a substantial health-care burden, despite recent
treatment advances. The key pathophysiological process that ultimately leads to chronic …

Background Ischemic mitral regurgitation is associated with a substantial risk of death.
Practice guidelines recommend surgery for patients with a severe form of this condition but …

Secondary (or functional) mitral regurgitation (SMR) occurs frequently in chronic heart failure
(HF) with reduced left ventricular (LV) ejection fraction, resulting from LV remodelling that …

Background Cardiac resynchronization therapy (CRT) is one of the most successful heart
failure therapies to emerge in the last 25 years and is applicable to∼ 25–30% of patients …

Objectives: The aim of this study was to determine the long-term effects of cardiac
resynchronization therapy (CRT) in the European cohort of patients enrolled in the …

Background: Guidelines recommend surgery for patients with severe ischemic mitral
regurgitation (MR). Nonrandomized studies suggest that subvalvular repair is associated …

Aims The aim of this first large-scale long-term study was to investigate whether obstructive
sleep apnoea (OSA) and/or central sleep apnoea (CSA) are associated with an increased …

Abstract Aims Predictors of Response to Cardiac Resynchronization Therapy
(CRT)(PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the …

Background The benefit of cardiac resynchronization therapy (CRT) among patients with
mild heart failure (HF), reduced left ventricular (LV) function and wide QRS is well …