Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

In vitro and ex vivo strategies for intracellular delivery

MP Stewart, A Sharei, X Ding, G Sahay, R Langer… - Nature, 2016 - nature.com
Intracellular delivery of materials has become a critical component of genome-editing
approaches, ex vivo cell-based therapies, and a diversity of fundamental research …

[HTML][HTML] A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing

AK Fajrial, QQ He, NI Wirusanti, JE Slansky, X Ding - Theranostics, 2020 - ncbi.nlm.nih.gov
Gene editing is a versatile technique in biomedicine that promotes fundamental research as
well as clinical therapy. The development of Clustered Regularly Interspaced Short …

State-of-the-art MEMS and microsystem tools for brain research

JP Seymour, F Wu, KD Wise, E Yoon - Microsystems & …, 2017 - nature.com
Mapping brain activity has received growing worldwide interest because it is expected to
improve disease treatment and allow for the development of important neuromorphic …

An enzyme‐coated metal–organic framework shell for synthetically adaptive cell survival

K Liang, JJ Richardson, CJ Doonan… - Angewandte Chemie …, 2017 - Wiley Online Library
A bioactive synthetic porous shell was engineered to enable cells to survive in an
oligotrophic environment. Eukaryotic cells (yeast) were firstly coated with a β‐galactosidase …

Advanced tools and methods for single-cell surgery

A Shakoor, W Gao, L Zhao, Z Jiang… - Microsystems & …, 2022 - nature.com
Highly precise micromanipulation tools that can manipulate and interrogate cell organelles
and components must be developed to support the rapid development of new cell-based …

Intracellular manipulation and measurement with multipole magnetic tweezers

X Wang, C Ho, Y Tsatskis, J Law, Z Zhang, M Zhu… - Science robotics, 2019 - science.org
The capability to directly interrogate intracellular structures inside a single cell for
measurement and manipulation is important for understanding subcellular and suborganelle …

Mechanical properties of single cells: Measurement methods and applications

Y Hao, S Cheng, Y Tanaka, Y Hosokawa… - Biotechnology …, 2020 - Elsevier
Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

Robotic micromanipulation: Fundamentals and applications

Z Zhang, X Wang, J Liu, C Dai… - Annual Review of Control …, 2019 - annualreviews.org
Robotic micromanipulation is a relatively young field. However, after three decades of
development and evolution, the fundamental physics; techniques for sensing, actuation, and …

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: at a glance

MM Rhaman, MR Islam, S Akash, M Mim… - Frontiers in Cell and …, 2022 - frontiersin.org
In recent decades, research scientists, molecular biologists, and pharmacologists have
placed a strong emphasis on cutting-edge nanostructured materials technologies to …