Aptamer-based detection of circulating targets for precision medicine
L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
Recent progress in aptamer discoveries and modifications for therapeutic applications
Aptamers are oligonucleotide sequences with a length of about 25–80 bases which have
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …
abilities to bind to specific target molecules that rival those of monoclonal antibodies. They …
Ligand-targeted drug delivery
M Srinivasarao, PS Low - Chemical reviews, 2017 - ACS Publications
Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …
[HTML][HTML] Nano-based drug delivery systems: Conventional drug delivery routes, recent developments and future prospects
Drug delivery can be defined as the group of approaches a drug or pharmacologically active
agent can be transported to the target cell to treat disease or health issue. Conventional …
agent can be transported to the target cell to treat disease or health issue. Conventional …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Aptamers as therapeutics
Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and
are commonly produced by systematic evolution of ligands by exponential enrichment …
are commonly produced by systematic evolution of ligands by exponential enrichment …
Recent advances in SELEX technology and aptamer applications in biomedicine
Z Zhuo, Y Yu, M Wang, J Li, Z Zhang, J Liu… - International journal of …, 2017 - mdpi.com
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with
high affinity and specificity. The process of selecting an aptamer is called Systematic …
high affinity and specificity. The process of selecting an aptamer is called Systematic …
New modalities for challenging targets in drug discovery
E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …
novel biological targets, whose modulation may enable novel therapeutic options for many …
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …
products for more than 40 years. These materials have evolved from their earlier use as …