The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …

Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Electrochemical C–N coupling reactions based on abundant small molecules (such as CO2
and N2) have attracted increasing attention as a new “green synthetic strategy” for the …

The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

Single-atom catalysts (SACs) have well-defined active sites, making them of potential
interest for organic synthesis,,–. However, the architecture of these mononuclear metal …

Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …

The ever increasing industrial production of commodity and specialty chemicals inexorably
depletes the finite primary fossil resources available on Earth. The forecast of population …

INTRODUCTION The ability to synthesize complex organic molecules is essential to the
discovery and manufacture of functional compounds, including small-molecule medicines …