Pathogenicity and virulence of Hepatitis B virus
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …
an estimated 296 million people in the world that are chronically infected by this virus, and …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Prospects for the global elimination of hepatitis B
Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core
Nuclear import of the hepatitis B virus (HBV) nucleocapsid is essential for replication that
occurs in the nucleus. The~ 360-angstrom HBV capsid translocates to the nuclear pore …
occurs in the nucleus. The~ 360-angstrom HBV capsid translocates to the nuclear pore …
Autophagic membranes participate in hepatitis B virus nucleocapsid assembly, precore and core protein trafficking, and viral release
Hepatitis B virus (HBV) DNA replication takes place inside the viral core particle and is
dependent on autophagy. Here we show that HBV core particles are associated with …
dependent on autophagy. Here we show that HBV core particles are associated with …
The hepatitis B virus nucleocapsid—dynamic compartment for infectious virus production and new antiviral target
M Niklasch, P Zimmermann, M Nassal - Biomedicines, 2021 - mdpi.com
Hepatitis B virus (HBV) is a small enveloped DNA virus which replicates its tiny 3.2 kb
genome by reverse transcription inside an icosahedral nucleocapsid, formed by a single …
genome by reverse transcription inside an icosahedral nucleocapsid, formed by a single …
Biogenesis and molecular characteristics of serum hepatitis B virus RNA
HBV is an enveloped DNA virus that replicates its DNA genome via reverse transcription of a
pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected …
pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected …
Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure
J Heger-Stevic, P Zimmermann, L Lecoq… - PLoS …, 2018 - journals.plos.org
Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse
transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of …
transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of …
[HTML][HTML] Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation
Hepatitis B virus (HBV) delivers a partially double-stranded, relaxed circular (RC) DNA
genome in complete virions to the host cell nucleus for conversion to the covalently closed …
genome in complete virions to the host cell nucleus for conversion to the covalently closed …
Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication
Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD)
and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role …
and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role …