Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll‐like receptors

EK Jo, CS Yang, CH Choi, CV Harding - Cellular microbiology, 2007 - Wiley Online Library
Toll‐like receptors (TLRs) recognize Mycobacterium tuberculosis (Mtb) or Mtb components
and initiate mononuclear phagocyte responses that influence both innate and adaptive …

Management of multidrug‐resistant tuberculosis: update 2007

WW Yew, CC Leung - Respirology, 2008 - Wiley Online Library
Multidrug‐resistant tuberculosis (MDR‐TB) with bacillary resistance to at least isoniazid and
rifampicin in vitro is a worldwide phenomenon. Hot spots of the disease are found scattered …

The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through …

SB Jung, CS Yang, JS Lee, AR Shin… - Infection and …, 2006 - Am Soc Microbiol
Although the 38-kDa glycolipoprotein of Mycobacterium tuberculosis H37Rv is known to
evoke prominent cellular and humoral immune responses in human tuberculosis (TB), little …

ASK1‐p38 MAPK‐p47phox activation is essential for inflammatory responses during tuberculosis via TLR2‐ROS signalling

CS Yang, DM Shin, HM Lee, JW Son… - Cellular …, 2008 - Wiley Online Library
The roles of intracellular reactive oxygen species (ROS) and related signalling pathways in
mycobacterial infection are largely unknown. Here we show that tuberculin purified protein …

New insights into biomarkers for evaluating therapy efficacy in pulmonary tuberculosis: A narrative review

F Zhang, F Zhang, Y Dong, L Li, Y Pang - Infectious Diseases and Therapy, 2023 - Springer
Evaluating therapy efficacy is crucial for patients with tuberculosis (TB), especially those with
drug-resistant tuberculosis (DR-TB). The World Health Organization currently recommends …

Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant …

L Geffner, N Yokobori, J Basile, P Schierloh… - Infection and …, 2009 - Am Soc Microbiol
In Argentina, multidrug-resistant tuberculosis (MDR-TB) outbreaks emerged among
hospitalized patients with AIDS in the early 1990s and thereafter disseminated to the …

[HTML][HTML] Mycobacterium tuberculosis PPE family protein Rv1808 manipulates cytokines profile via co-activation of MAPK and NF-κB signaling pathways

W Deng, W Li, J Zeng, Q Zhao, C Li, Y Zhao… - Cellular Physiology and …, 2014 - karger.com
Background/Aims: Mycobacterium tuberculosis is an extremely successful intracellular
pathogen armed with multiple tactics to subvert host immunity. PPE (Pro-Pro-Glu) family …

Mycobacterium tuberculosis Rv3402c Enhances Mycobacterial Survival within Macrophages and Modulates the Host Pro-Inflammatory Cytokines Production via NF …

W Li, Q Zhao, W Deng, T Chen, M Liu, J Xie - PloS one, 2014 - journals.plos.org
Intracellular survival plays a central role in the pathogenesis of Mycobacterium tuberculosis,
a process which depends on an array of virulence factors to colonize and replicate within the …

Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion

LP Samuel, CH Song, J Wei, EA Roberts… - …, 2007 - microbiologyresearch.org
The eis gene of Mycobacterium tuberculosis has been shown to play a role in the survival of
the avirulent Mycobacterium smegmatis within the macrophage. In vitro and in vivo analysis …

Иммунопатология туберкулеза легких

ОВ Воронкова, ОИ Уразова, ВВ Новицкий… - 2007 - elibrary.ru
В монографии обобщены данные современной литературы относительно
иммунопатологии туберкулезной инфекции и описание результатов собственных …