The newly characterized sperm-specific Na+/H+ exchanger stands out by its unique tripartite
domain composition,. It unites a classical solute carrier unit with regulatory domains usually …

Ether-a-go-go (EAG) potassium selective channels are major regulators of neuronal
excitability and cancer progression. EAG channels contain a Per–Arnt–Sim (PAS) domain in …

Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels
facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain …

Hyperpolarization-activated cyclic nucleotide–modulated (HCN) channels are tetramers that
elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels …

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are promising
therapeutic targets because of their association with the genesis of several diseases. The …

cyclic GMP-AMP (2′ 3′-cGAMP), generated by cyclic GMP-AMP synthase (cGAS) under
activation by cytosolic DNA, has a vital role in innate immune response via its receptor …

Protein cysteine thiol status is a major determinant of oxidative stress and oxidant signaling.
The-SulfoBiotics-Protein Redox State Monitoring Kit provides a unique opportunity to …

Ion channels are transmembrane proteins essential for cellular functions and are important
drug targets. Surface plasmon resonance (SPR) is a powerful technique for investigating …

Background KCNH family of potassium channels is responsible for diverse physiological
functions ranging from the regulation of neuronal excitability and cardiac contraction to the …

We have previously reported the inhibition of bacterial topoisomerase I activity by a
fluoroquinophenoxazine compound (FP-11g) with a 6-bipiperidinyl lipophilic side chain that …