Aquaporin 4 and neuromyelitis optica

MC Papadopoulos, AS Verkman - The Lancet Neurology, 2012 - thelancet.com
Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …

Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

MR Aburto, JF Cryan - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

MC Papadopoulos, JL Bennett… - Nature Reviews …, 2014 - nature.com
Neuromyelitis optica (NMO) is an autoimmune disease of the CNS that is characterized by
inflammatory demyelinating lesions in the spinal cord and optic nerve, potentially leading to …

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

CE Johanson, JA Duncan, PM Klinge, T Brinker… - Cerebrospinal fluid …, 2008 - Springer
This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics:
formation rate, pressure, flow, volume, turnover rate, composition, recycling and …

The blood–cerebrospinal fluid barrier: structure and functional significance

CE Johanson, EG Stopa, PN McMillan - The Blood-Brain and Other …, 2011 - Springer
The choroid plexus (CP) of the blood–CSF barrier (BCSFB) displays fundamentally different
properties than blood-brain barrier (BBB). With brisk blood flow (10× brain) and highly …

Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia

JC Ayus, SG Achinger, A Arieff - American Journal of …, 2008 - journals.physiology.org
Hyponatremia is the most common electrolyte abnormality in hospitalized patients. When
symptomatic (hyponatremic encephalopathy), the overall morbidity is 34%. Individuals most …

Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury

SJA Davies, CH Shih, M Noble, M Mayer-Proschel… - PloS one, 2011 - journals.plos.org
Repairing trauma to the central nervous system by replacement of glial support cells is an
increasingly attractive therapeutic strategy. We have focused on the less-studied …

Pregnancy outcomes in aquaporin-4–positive neuromyelitis optica spectrum disorder

MM Nour, I Nakashima, E Coutinho, M Woodhall… - Neurology, 2016 - AAN Enterprises
Objective: To investigate the association between neuromyelitis optica spectrum disorder
(NMOSD) and pregnancy outcome. Methods: An international cohort of women with …

Neuromyelitis optica IgG causes placental inflammation and fetal death

S Saadoun, P Waters, MI Leite, JL Bennett… - The Journal of …, 2013 - journals.aai.org
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the CNS and
affects women of childbearing age. Most patients with NMO have circulating Abs, termed …

Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: possible role in edema resolution?

AM Fukuda, V Pop, D Spagnoli, S Ashwal, A Obenaus… - Neuroscience, 2012 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of death and disability in children
and adolescents. The neuropathological sequelae that result from TBI are a complex …