Medical genetics was revolutionized during the 1980s by the application of genetic mapping
to locate the genes responsible for simple Mendelian diseases. Most diseases and traits …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

Abnormalities of prefrontal cortical function are prominent features of schizophrenia and
have been associated with genetic risk, suggesting that susceptibility genes for …

Background Velo-cardio-facial syndrome (VCFS), a syndrome characterized by an
increased frequency of schizophrenia and bipolar disorder, is associated with small …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

Heart failure (HF) and type 2 diabetes mellitus (T2DM) are both growing public health
concerns contributing to major medical and economic burdens to society. T2DM increases …

We report the results of two studies examining the genetic overlap between schizophrenia
and velocardiofacial syndrome. In study A, we characterize two interstitial deletions …

This article reviews prefrontal cortical biology as it relates to pathophysiology and genetic
risk for schizophrenia. Studies of prefrontal neurocognition and functional neuroimaging of …

Background The α7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has
been implicated as a candidate gene for schizophrenia, and for an auditory sensory …

BackgroundData from family, twin and adoption studies show overwhelming evidence of a
substantial genetic component in schizophrenia and although molecular genetic studies …