Purpose Since the exact development of posterior subcapsular cataracts (PSCs) is poorly
understood, we review various risk factors and propose a two-stage etiology for PSCs …

In order to accomplish its function of transmitting and focusing light, the crystalline lens of the
vertebrate eye has evolved a unique cellular structure and protein complement. These …

Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

Life-long eye lens function requires an appropriate gradient refractive index, biomechanical
integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1 …

The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …

Cataracts are the principal cause of treatable blindness worldwide. Inherited congenital
cataract (CC) shows all types of inheritance patterns in a syndromic and nonsyndromic form …

Gap junction-mediated intercellular communication facilitates the circulation of ions, small
molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap …

The lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. Alterations to the refractive properties of the …

The transparency and refractive properties of the lens are maintained by the cellular
physiology provided by an internal microcirculation system that utilizes spatial differences in …

In wild-type lenses from various species, an intracellular hydrostatic pressure gradient goes
from∼ 340 mmHg in central fiber cells to 0 mmHg in surface cells. This gradient drives a …