Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

Nature provides a variety of peptides that are expressed in most living species. Evolutionary
pressure and natural selection have created and optimized these peptides to bind to …

Despite their recognized limitations, bibliometric assessments of scientific productivity have
been widely adopted. We describe here an improved method to quantify the influence of a …

The aberrant proliferation of tumor cells and abundant vasculature in tumor tissues are
closely correlated with receptors that are specifically dysregulated in tumor cells. These …

G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …

Drug discovery is a laborious process with rising cost per new drug. Peptide macrocycles
are promising therapeutics, though conformational flexibility can reduce target affinity and …

The purpose of our review is to briefly show what different compounds of marine origin, from
low molecular weight ones to peptides and proteins, offer for understanding the structure …

Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides
both as a defense mechanism and as a means to immobilize and kill their prey. These …

Various kinds of animal venoms and their components have been widely studied for
potential therapeutic applications. This study evaluated whether Nemopilema nomurai …

The Conus genus includes around 500 species of marine mollusks with a peculiar
production of venomous peptides known as conotoxins (CTX). Each species is able to …