Cellular and systemic effects of anthrax lethal toxin and edema toxin
M Moayeri, SH Leppla - Molecular aspects of medicine, 2009 - Elsevier
Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and
can replicate the lethality and symptoms associated with the disease. This review provides …
can replicate the lethality and symptoms associated with the disease. This review provides …
[HTML][HTML] Molecular pathogenesis of Bacillus anthracis infection
SF Little, BE Ivins - Microbes and Infection, 1999 - Elsevier
This review summarizes the current knowledge pertaining to the pathogenesis of infection
with Bacillus anthracis relative to the two exotoxins and the capsule. Emphasis is given to …
with Bacillus anthracis relative to the two exotoxins and the capsule. Emphasis is given to …
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
SL Fink, T Bergsbaken… - Proceedings of the …, 2008 - National Acad Sciences
Caspase-1 cleaves the inactive IL-1β and IL-18 precursors into active inflammatory
cytokines. In Salmonella-infected macrophages, caspase-1 also mediates a pathway of …
cytokines. In Salmonella-infected macrophages, caspase-1 also mediates a pathway of …
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.
KR Klimpel, SS Molloy, G Thomas… - Proceedings of the …, 1992 - National Acad Sciences
Proteolytic cleavage of the protective antigen (PA) protein of anthrax toxin at residues 164-
167 is necessary for toxic activity. Cleavage by a cellular protease at this sequence, Arg-Lys …
167 is necessary for toxic activity. Cleavage by a cellular protease at this sequence, Arg-Lys …
[HTML][HTML] Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides.
N Arora, SH Leppla - Journal of Biological Chemistry, 1993 - Elsevier
Anthrax lethal toxin is a complex of protective antigen (PA, 735 amino acids) and lethal
factor (LF, 776 amino acids) that lyses certain eukaryotic cells. LF interacts with PA to gain …
factor (LF, 776 amino acids) that lyses certain eukaryotic cells. LF interacts with PA to gain …
Manipulation of host signalling pathways by anthrax toxins
BE Turk - Biochemical Journal, 2007 - portlandpress.com
Infectious microbes face an unwelcoming environment in their mammalian hosts, which
have evolved elaborate multicelluar systems for recognition and elimination of invading …
have evolved elaborate multicelluar systems for recognition and elimination of invading …
[HTML][HTML] Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of …
The lethal factor (LF) and edema factor (EF) components of anthrax toxin are toxic to animal
cells only if internalized by interaction with the protective antigen (PA) component. PA binds …
cells only if internalized by interaction with the protective antigen (PA) component. PA binds …
Anthrax toxin
SH Leppla - Bacterial protein toxins, 2000 - Springer
The virulence of Bacillus anthracis depends principally on two extracellular products, an
antiphagocytic POlY-YD-glutamic acid capsule, and a threecomponent protein exotoxin …
antiphagocytic POlY-YD-glutamic acid capsule, and a threecomponent protein exotoxin …
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo
Y Singh, VK Chaudhary, SH Leppla - Journal of Biological Chemistry, 1989 - ASBMB
Anthrax toxin is the only protein secreted by Bacillus anthracis that contributes to the
virulence of this bacterium. An obligatory step in the action of anthrax toxin on eukaryotic …
virulence of this bacterium. An obligatory step in the action of anthrax toxin on eukaryotic …
Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal anti bodies
SF Little, JM Novak, JR Lowe, SH Leppla… - …, 1996 - microbiologyresearch.org
Lethal toxin from Bacillus anthracisis composed of protective antigen (PA) and lethal factor
(LF). Anti-PA mAbs that neutralized lethal toxin activity, either in vivo or in vitro, identified …
(LF). Anti-PA mAbs that neutralized lethal toxin activity, either in vivo or in vitro, identified …