[HTML][HTML] Small molecule inhibitors of CXCR4
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …
Imaging agents for the chemokine receptor 4 (CXCR4)
J Kuil, T Buckle, FWB van Leeuwen - Chemical Society Reviews, 2012 - pubs.rsc.org
The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-
1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body …
1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body …
Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells
To date, challenges in the design of bivalent ligands for G protein-coupled receptors
(GPCRs) have revealed difficulties stemming from lack of knowledge of the state of …
(GPCRs) have revealed difficulties stemming from lack of knowledge of the state of …
Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres
T Narumi, R Hayashi, K Tomita, K Kobayashi… - Organic & …, 2010 - pubs.rsc.org
A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo (-D-Tyr-Arg-
Arg-Nal-Gly-)] were synthesized and bioevaluated. Using (E)-alkene and (Z)-fluoroalkene …
Arg-Nal-Gly-)] were synthesized and bioevaluated. Using (E)-alkene and (Z)-fluoroalkene …
Advances in machine intelligence‐driven virtual screening approaches for big‐data
Virtual screening (VS) is an integral and ever‐evolving domain of drug discovery framework.
The VS is traditionally classified into ligand‐based (LB) and structure‐based (SB) …
The VS is traditionally classified into ligand‐based (LB) and structure‐based (SB) …
Discovery of tetrahydroisoquinoline-containing CXCR4 antagonists with improved in vitro ADMET properties
EJ Miller, E Jecs, VM Truax, BM Katzman… - Journal of Medicinal …, 2018 - ACS Publications
CXCR4 is a seven-transmembrane receptor expressed by hematopoietic stem cells and
progeny, as well as by≥ 48 different cancers types. CXCL12, the only chemokine ligand of …
progeny, as well as by≥ 48 different cancers types. CXCL12, the only chemokine ligand of …
Positron emission tomographic imaging of CXCR4 in cancer: challenges and promises
GPC George, F Pisaneschi, QD Nguyen… - Molecular …, 2015 - journals.sagepub.com
Molecular imaging is an attractive platform for noninvasive detection and assessment of
cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4) …
cancer. In recent years, the targeted imaging of the C–X–C chemokine receptor 4 (CXCR4) …
Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands
MM Sakyiamah, T Kobayakawa, M Fujino… - Bioorganic & Medicinal …, 2019 - Elsevier
The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling
axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 …
axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 …
Azamacrocyclic metal complexes as CXCR4 antagonists
The chemokine receptor CXCR4 is a member of the seven transmembrane GPCR family,
which is implicated in multiple diseases, including HIV infection, cancers, and rheumatoid …
which is implicated in multiple diseases, including HIV infection, cancers, and rheumatoid …
Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)
S Oishi, N Fujii - Organic & biomolecular chemistry, 2012 - pubs.rsc.org
The development of novel peptide and peptidomimetic ligands for the CXC chemokine
receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system …
receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system …