In view of the multifunctional features of coumarins and chalcones, coumarin–chalcone
hybrids have attracted much attention in recent years. Herein, the free radical scavenging …

AIM: To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular
model of hepatic steatosis. METHODS: Rat hepatoma FaO cells were loaded with lipids by …

p-Coumaric acid is a ubiquitous molecule, widely distributed in the vegetal kingdom and
often found in the human diet. A systematic, rational search for new p-coumaric acid …

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and
mortality. Oxidative stress and release of pro-inflammatory cytokines, such as tumor necrosis …

Silymarin, a standardized extract of the seeds of the milk thistle (Silybum marianum) and its
major component, silybin, is now used as an active component in a broad spectrum of …

Overconsumption of fats and sugars is a major cause of development of non‑alcoholic fatty
liver disease (NAFLD). The main objectives of the present study were to explore the …

Quercetin, one of the most abundant polyphenols in the plant kingdom has been shown to
be photodegraded on exposure to UV light. Despite the fact, it is a component of several …

The antiradical properties and possible mechanisms of action of the tautomers of curcumin,
caffeic acid phenethyl ester (CAPE), and chicoric acid (CA) have been studied within density …

Free radicals are very reactive molecules that produce so-called oxidative stress. To prevent
oxidative stress there are two types of molecules: primary and secondary antioxidants. The …

We analyze the free radical scavenger capacity of silybin-metal clusters systems by applying
Density Functional Theory (DFT) calculations, following two well-known antioxidant …