Self-emulsifying drug delivery systems: An alternative approach to improve brain bioavailability of poorly water-soluble drugs through intranasal administration

S Meirinho, M Rodrigues, AO Santos, A Falcão… - Pharmaceutics, 2022 - mdpi.com
Efforts in discovering new and effective neurotherapeutics are made daily, although most fail
to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous …

Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances

R Verma, V Mittal, P Pandey, S Bhatia… - Current Drug …, 2023 - ingentaconnect.com
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …

3D printing of dapagliflozin containing self-nanoemulsifying tablets: Formulation design and in vitro characterization

MS Algahtani, AA Mohammed, J Ahmad, MM Abdullah… - Pharmaceutics, 2021 - mdpi.com
The 3D printing techniques have been explored extensively in recent years for
pharmaceutical manufacturing and drug delivery applications. The current investigation …

Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates exceptional efficiency in amelioration of peptic ulcer

WA El-Dakroury, MB Zewail, M Elsabahy… - International Journal of …, 2022 - Elsevier
Famotidine (FMD) is a highly potent H 2-receptor antagonist used in peptic ulcer treatment.
However, the drug possesses poor aqueous solubility and permeability. FMD-loaded solid …

The enhanced pH-dependent solubility behavior of three novel lamotrigine-acid salts

J Li, Y Zhu, C Zhang, D Yang, Y Lu, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Lamotrigine (LAM), a Biopharmaceutics Classification System (BCS) class II drug, is
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …

Development and exploration on flowability of solid self-nanoemulsifying drug delivery system of morin hydrate

PV Dangre, SB Shinde, SJ Surana, PG Jain… - Advanced Powder …, 2022 - Elsevier
Morin hydrate (MH) is a promising flavonoid with diverse biological activities; unfortunately, it
finds limited clinical application due to its low water solubility. Herein, we developed a liquid …

Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy

AM Mohsen, AAA Salama… - Pharmaceutical …, 2023 - Taylor & Francis
Lamotrigine (LTG) is a second-generation antiepileptic drug that belongs to
Biopharmaceutics Classification System (BCS) class II. LTG has a low probability of crossing …

SEDDS basic design and recent formulation advancement: a concurrent review

KC Panigrahi, CN Patra, MEB Rao… - Pharmaceutical …, 2022 - ingentaconnect.com
In the present scenario, lipid-based novel drug delivery systems are the area of interest for
the formulation scientist in order to improve the bioavailability of poorly water-soluble drugs …

Genetics of Dravet Syndrome and Its Targeted Therapy by Nanomedicine: A Roadmap for Future Treatment of Drug Resistant Seizures

M Ikram, S Rasheed - Current Molecular Pharmacology, 2023 - ingentaconnect.com
According to the World Health Organization (WHO), epilepsy is the 4th most prevalent
neurological disorder after migraine, stroke, and Alzheimer's disease. There are numerous …

Pharmaceutical Modifications of Capsaicin to Enhance its Bioavailability

M Prashar, N Dhingra, S Raj - … : From Natural Sources to Biosynthesis and …, 2024 - Springer
Abstract Capsaicin or N-vanillyl-8-methyl-6-(E)-none amide, a unique key constituent from
the Capsicum genus, is a pharmaceutical agent with a wide range of therapeutic …