Converting nanotoxicity data to information using artificial intelligence and simulation
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …
However, data is not equal to information. The question is how to extract critical information …
[HTML][HTML] Computer-aided nanodrug discovery: recent progress and future prospects
JJ Zheng, QZ Li, Z Wang, X Wang, Y Zhao… - Chemical Society …, 2024 - pubs.rsc.org
Nanodrugs, which utilise nanomaterials in disease prevention and therapy, have attracted
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …
considerable interest since their initial conceptualisation in the 1990s. Substantial efforts …
Distinguishing the nanoplastic–cell membrane interface by polymer type and aging properties: translocation, transformation and perturbation
L Li, S Li, Y Xu, L Ren, L Yang, X Liu, Y Dai… - Environmental …, 2023 - pubs.rsc.org
Nanoscale plastics, being ubiquitous in the environment, can cross biological barriers
primarily through interactions with the cell membrane; yet there remains a lack of knowledge …
primarily through interactions with the cell membrane; yet there remains a lack of knowledge …
Thermal-controlled cellular uptake of “hot” nanoparticles
Nanoparticles (NPs) have shown immense potential in the field of biomedical applications,
particularly in NP-based photothermal therapy, which offers a remote-controlled approach to …
particularly in NP-based photothermal therapy, which offers a remote-controlled approach to …
Membrane-specific binding of 4 nm lipid nanoparticles mediated by an entropy-driven interaction mechanism
L Ou, H Chen, B Yuan, K Yang - ACS nano, 2022 - ACS Publications
Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …
Co-Administration of transportan peptide enhances the cellular entry of liposomes in the bystander manner both in vitro and in vivo
Liposomes have been widely used as a drug delivery vector. One way to further improve its
therapeutic efficacy is to increase the cell entry efficiency. Covalent conjugation with cell …
therapeutic efficacy is to increase the cell entry efficiency. Covalent conjugation with cell …
A computational study of the influence of nanoparticle shape on clathrin-mediated endocytosis
Y Li, M Zhang, Y Zhang, X Niu, Z Liu, T Yue… - Journal of Materials …, 2023 - pubs.rsc.org
Nanoparticles have been widely used in biomedical applications such as gene/drug
delivery, molecular imaging and diagnostics. Among the physicochemical properties, shape …
delivery, molecular imaging and diagnostics. Among the physicochemical properties, shape …
Insight into biophysicochemical principles of biopolymers through simulation and theory
The development of biopolymers for biomedical applications has traditionally been based
on new chemistries. However, there is growing recognition that the biological responses can …
on new chemistries. However, there is growing recognition that the biological responses can …
Computational study on the regulatory mechanism of cell membrane wrapping on liposomes by embedded bowl-like nanostructures for drug delivery
R Kang, S Li, Y Li, X Zhang, T Yue - ACS Applied Nano Materials, 2022 - ACS Publications
Controlling the nanoparticle's (NP) ability to facilitate cell uptake is particularly desirable for
biomedical applications, such as drug delivery. Despite growing evidence highlighting the …
biomedical applications, such as drug delivery. Despite growing evidence highlighting the …
Energy and Speed Landscapes of the Membrane Internalization Behavior of Soft Nanoparticles
Z Zhang, L Ou, K Yang, B Yuan - The Journal of Physical …, 2024 - ACS Publications
The cellular endocytosis of nanoparticles (NPs) is a fundamental biological process with
significant potential in biomedical applications. However, a comprehensive understanding of …
significant potential in biomedical applications. However, a comprehensive understanding of …