Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory
responses that promote the rapid clearance of pathogens but also contribute to pathology in …

Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived
with a circulating half life of 6–8h and hence are produced at a rate of 5× 10 10–10× 10 10 …

Innate myeloid immune cells, and neutrophils in particular, serve as first line of defense
against pathogenic microorganisms including bacteria and fungi. Given their short life span …

The in vivo function of murine granulocyte-macrophage colony-stimulating factor (GM-CSF)
was investigated in mice, carrying a null allele of the GM-CSF gene, that were generated by …

Mice homozygous for a disrupted granulocyte/macrophage colony-stimulating factor (GM-
CSF) gene develop normally and show no major perturbation of hematopoiesis up to 12 …

The endothelium forms a vast network that dynamically regulates vascular barrier function,
coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …