Abstract Aim The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure”
replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the …

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

ESC Guidelines e341 (1) the specific situation of the patient. In this respect, it is specified
that, unless otherwise provided for by national regulations, offlabel use of medication should …

Purpose Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies
that can interfere with the efficacy of treatment, decrease quality of life, or impact the actual …

Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …

Purpose Cardiovascular diseases (CVDs), including ischemic heart disease, stroke, and
heart failure, are well-established late effects of therapy in survivors of childhood and young …

Heart failure (HF) continues to be a major contributor of morbidity and mortality for men and
women alike, yet how the predisposition for, course and management of HF differ between …

The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of
cardiotoxicity. It has been calculated that approximately 10% of patients treated with …

The task of developing CPG documents covers not only integration of the most recent
research, but also the creation of educational tools and implementation programmes for the …

Background We conducted a systematic review and meta-analysis to clarify the risk of early
and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian …