Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …

Despite antiretroviral therapy (ART) which halts HIV-1 replication and reduces plasma viral
load to clinically undetectable levels, viral rebound inevitably occurs once ART is …

Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …

Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of
proviral integration sites. However, the source of the proliferation of HIV-infected cells …

Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian
immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) …

HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of
different anatomical compartments to the viral reservoir in humans remains unknown. We …

Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …

Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …