Cells from organisms with renewable tissues can permanently withdraw from the cell cycle
in response to diverse stress, including dysfunctional telomeres, DNA damage, strong …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

MicroRNAs are noncoding RNAs of∼ 22 nucleotides that suppress translation of target
genes by binding to their mRNA and thus have a central role in gene regulation in health …

Cellular senescence suppresses cancer by preventing the proliferation of cells that
experience potentially oncogenic stimuli. Senescent cells often express p16 INK4a, a cyclin …

Cellular senescence is a program activated by normal cells in response to various types of
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …

Abstract The INK4b–ARF–INK4a locus encodes two members of the INK4 family of cyclin-
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …

The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated
by members of the Polycomb group (PcG) of transcriptional repressors. Here we show that …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

Telomere attrition in primary human fibroblasts induces replicative senescence
accompanied by activation of the p53 and p16 INK4a/RB tumor suppressor pathways …

Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …