The emerging landscape of immune cell therapies
Cell therapies present an entirely new paradigm in drug development. Within this class,
immune cell therapies are among the most advanced, having already demonstrated …
immune cell therapies are among the most advanced, having already demonstrated …
Manufacturing chimeric antigen receptor T cells: issues and challenges
Clinical trials of adoptively transferred CD19 chimeric antigen receptor (CAR) T cells have
delivered unprecedented responses in patients with relapsed refractory B-cell malignancy …
delivered unprecedented responses in patients with relapsed refractory B-cell malignancy …
Emerging strategies in TCR-engineered T cells
Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated
by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient …
by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient …
Mixed T cell receptor dimers harbor potentially harmful neoreactivity
MM van Loenen, R de Boer, AL Amir… - Proceedings of the …, 2010 - National Acad Sciences
Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to
target both hematological malignancies and solid tumors. By introducing a TCR, large …
target both hematological malignancies and solid tumors. By introducing a TCR, large …
Adoptive cell therapy for cancer treatment
Adoptive cell therapy (ACT) is a rapidly growing anti‐cancer strategy that has shown
promise in treating various cancer types. The concept of ACT involves activating patients' …
promise in treating various cancer types. The concept of ACT involves activating patients' …
Adoptive immunotherapy for cancer
M Ruella, M Kalos - Immunological reviews, 2014 - Wiley Online Library
Recent clinical success has underscored the potential for immunotherapy based on the
adoptive cell transfer (ACT) of engineered T lymphocytes to mediate dramatic, potent, and …
adoptive cell transfer (ACT) of engineered T lymphocytes to mediate dramatic, potent, and …
Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR
S Okamoto, J Mineno, H Ikeda, H Fujiwara… - Cancer research, 2009 - AACR
Adoptive T-cell therapy using lymphocytes genetically engineered to express tumor antigen-
specific TCRs is an attractive strategy for treating patients with malignancies. However, there …
specific TCRs is an attractive strategy for treating patients with malignancies. However, there …
Minimal amino acid exchange in human TCR constant regions fosters improved function of TCR gene-modified T cells
D Sommermeyer, W Uckert - The Journal of Immunology, 2010 - journals.aai.org
TCR gene therapy using adoptive transfer of TCR gene-modified T cells is a new strategy for
treatment of cancer. One critical prerequisite for TCR gene therapy is sufficient expression of …
treatment of cancer. One critical prerequisite for TCR gene therapy is sufficient expression of …
Off-the-shelf allogeneic T cell therapies for cancer: opportunities and challenges using naturally occurring “universal” donor T cells
Chimeric antigen receptor (CAR) engineered T cell therapies individually prepared for each
patient with autologous T cells have recently changed clinical practice in the management of …
patient with autologous T cells have recently changed clinical practice in the management of …
CD3 limits the efficacy of TCR gene therapy in vivo
The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface
expression of the introduced TCR α/β heterodimer. We tested whether endogenous CD3 …
expression of the introduced TCR α/β heterodimer. We tested whether endogenous CD3 …