Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …

The self-formation of retinal tissue from pluripotent stem cells generated a tremendous
promise for developing new therapies of retinal degenerative diseases, which previously …

Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they
not only mediate and control the transfer of fluids and solutes but also protect the retina …

Nicotine, the main chemical constituent of tobacco, is highly detrimental to the developing
fetus by increasing the risk of gestational complications and organ disorders. The effects of …

Abstract Background Neural stem cells (NSCs) are able to differentiate into neurons and
astroglia. miRNAs have been demonstrated to be involved in NSC self-renewal, proliferation …

The Notch pathway is remarkably simple without the interventions of secondary
messengers. It possesses a unique receptor–ligand interaction that imparts signaling upon …

Within the vascular endothelial growth factor (VEGF) family of five subtypes, VEGF165
secreted by endothelial cells has been identified to be the most active and widely distributed …

Elevated Notch signaling has been verified in a large range of fibrotic diseases developed in
the kidney, liver, and lung, inducing the development of the epithelial–mesenchymal …

Background This study aimed to explore the effects of plumbagin (PLB) on ARPE-19 cells
and underlying mechanism. Methods Cultured ARPE-19 cells were treated with various …

Abstract miR-183/96/182 cluster plays a critical role in the developing retina by regulating
many target genes involved in signaling pathways. This study aimed to survey the miR …