Multi-functional antibody profiling for malaria vaccine development and evaluation
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
IgM in human immunity to Plasmodium falciparum malaria
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G
(IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to …
(IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to …
The GMZ2 malaria vaccine: from concept to efficacy in humans
Introduction: GMZ2 is a recombinant protein consisting of conserved domains of GLURP and
MSP3, two asexual blood-stage antigens of Plasmodium falciparum, and is designed with …
MSP3, two asexual blood-stage antigens of Plasmodium falciparum, and is designed with …
[HTML][HTML] Plasmodium falciparum–specific IgM B cells dominate in children, expand with malaria, and produce functional IgM
CS Hopp, P Sekar, A Diouf, K Miura… - The Journal of …, 2021 - ncbi.nlm.nih.gov
IgG antibodies play a role in malaria immunity, but whether and how IgM protects from
malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a …
malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a …
The prevalence of submicroscopic Plasmodium falciparum gametocyte carriage and multiplicity of infection in children, pregnant women and adults in a low malaria …
Background The gametocyte stage of Plasmodium falciparum is considered an important
target for disrupting malaria transmission. Indications are that various demographic groups …
target for disrupting malaria transmission. Indications are that various demographic groups …
First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)
S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …
GMZ2 vaccine-induced antibody responses, naturally acquired immunity and the incidence of malaria in burkinabe children
GMZ2 is a malaria vaccine candidate evaluated in a phase 2b multi-centre trial. Here we
assessed antibody responses and the association of naturally acquired immunity with …
assessed antibody responses and the association of naturally acquired immunity with …
Selection of Antibody Responses Associated With Plasmodium falciparum Infections in the Context of Malaria Elimination
LL Van den Hoogen, G Stresman, J Présumé… - Frontiers in …, 2020 - frontiersin.org
In our aim to eliminate malaria, more sensitive tools to detect residual transmission are
quickly becoming essential. Antimalarial antibody responses persist in the blood after a …
quickly becoming essential. Antimalarial antibody responses persist in the blood after a …
A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda
SJ Gonzales, KN Clarke, G Batugedara… - Frontiers in …, 2022 - frontiersin.org
Memory B cells (MBCs) and plasma antibodies against Plasmodium falciparum (Pf)
merozoite antigens are important components of the protective immune response against …
merozoite antigens are important components of the protective immune response against …
Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium …
C Dechavanne, S Dechavanne, I Sadissou… - PLoS …, 2017 - journals.plos.org
Background Transplacental transfer of maternal immunoglobulin G (IgG) to the fetus helps to
protect against malaria and other infections in infancy. Recent studies have emphasized the …
protect against malaria and other infections in infancy. Recent studies have emphasized the …