Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives
D He, M Wang, S Zhao, Y Shu, H Zeng, C Xiao, C Lu… - Fitoterapia, 2017 - Elsevier
Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted
increasing interest because of their broad spectrum of biological functions. This review …
increasing interest because of their broad spectrum of biological functions. This review …
Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus
Quinazolinones, which represent an important part of nitrogen‐containing six‐membered
heterocyclic compounds, are frequently used in drug design due to their wide biological …
heterocyclic compounds, are frequently used in drug design due to their wide biological …
Synthesis and Evaluation of Quinazolin‐4(3H)‐one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry‐Oriented Drug Design
In this study, imines bearing quinazolin‐4 (3H)‐one were synthesized and their inhibitory
properties were investigated against some metabolic enzymes including …
properties were investigated against some metabolic enzymes including …
Quinazolinones, the winning horse in drug discovery
AM Alsibaee, HM Al-Yousef, HS Al-Salem - Molecules, 2023 - mdpi.com
Quinazolines are nitrogen-containing heterocycles that consist of a benzene ring fused with
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC)
T790M mutation is the most common mechanism of acquired resistance to first-generation
epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). To overcome this …
epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). To overcome this …
Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity
In the current research, methaqualone derivatives were synthesized and assessed for their
anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti …
anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti …
New amino acid Schiff bases as anticancer agents via potential mitochondrial complex I-associated hexokinase inhibition and targeting AMP-protein kinases/mTOR …
Two series of novel amino acid Schiff base ligands containing heterocyclic moieties, such as
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
quinazolinone 3–11 and indole 12–20 were successfully synthesized and confirmed by …
Structural insights into GABAA receptor potentiation by Quaalude
Methaqualone, a quinazolinone marketed commercially as Quaalude, is a central nervous
system depressant that was used clinically as a sedative-hypnotic, then became a notorious …
system depressant that was used clinically as a sedative-hypnotic, then became a notorious …
A series of quinazolin‐4(3H)‐one‐morpholine hybrids as anti‐lung‐cancer agents: Synthesis, molecular docking, molecular dynamics, ADME prediction and …
In this study, we synthesized 15 novel quinazoline‐morpholinobenzylideneamino hybrid
compounds from methyl anthranilate and we assessed their cytotoxicity via in vitro assays …
compounds from methyl anthranilate and we assessed their cytotoxicity via in vitro assays …
Design and synthesis of quinazolinones as EGFR inhibitors to overcome EGFR resistance obstacle
The epidermal growth factor receptor (EGFR) T790M mutant is found in about 50% of
clinically acquired resistance to gefitinib among patients with non-small cell lung cancer …
clinically acquired resistance to gefitinib among patients with non-small cell lung cancer …