RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

The field of structural biology has the unique advantage of being able to provide a
comprehensive picture of biological mechanisms at the molecular and atomic level. Long …

Protein flexibility ranges from simple hinge movements to functional disorder. Around half of
all human proteins contain apparently disordered regions with little 3D or functional …

Understanding how ligands bind to ribonucleic acids (RNA) is important for understanding
RNA recognition in biological processes and drug development. Here, we have studied …

The HIV Tat protein competes with the 7SK: HEXIM interaction to hijack pTEFb from 7SK
snRNP and recruit it to the TAR motif on stalled viral transcripts. Here we solve structures of …

The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

HIV-1 Rev is an~ 13 kD accessory protein expressed during the early stage of virus
replication. After translation, Rev enters the nucleus and binds the Rev response element …

The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …

The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced
and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response …

Two non-covalently linked copies of the retrovirus genome are specifically recruited to the
site of virus particle assembly and packaged into released particles. Retroviral RNA …