Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …

Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

The hypothalamic-pituitary-adrenal (HPA) axis is a major component of the systems that
respond to stress, by coordinating the neuroendocrine and autonomic responses. Tightly …

Research has elucidated causal links between stress exposure and the development of
anxiety disorders, but due to the limited use of female or sex-comparative animal models …

Despite that burnout presents a serious burden for modern society, there are no diagnostic
criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there …

Major depressive disorder is a chronic, remitting syndrome involving widely distributed
circuits in the brain. Stable alterations in gene expression that contribute to structural and …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …