The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate
dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two …

Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors
of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

Background Paragangliomas and phaeochromocytomas are neuroendocrine tumours
associated frequently with germline mutations of SDHD, SDHC, and SDHB. Previous studies …

A genetic predisposition for paragangliomas and adrenal or extra‐adrenal
phaeochromocytomas was recognized years ago. Beside the well‐known syndromes …

Carney triad (CT) is a rare condition with synchronous or metachronous occurrence of
gastrointestinal stromal tumors (GISTs), paragangliomas (PGLs), and pulmonary …

Mitochondrial complex II (CII) has been recently identified as a novel target for anti-cancer
drugs. Mitochondrially targeted vitamin E succinate (MitoVES) is modified so that it is …

Pheochromocytomas and paragangliomas (PCC/PGL) are tumors derived from the adrenal
medulla or extra-adrenal ganglia, respectively. They are rare and often benign tumors that …

Context.—Advances in genetics and gene expression profiling have led to new ways of
thinking about the pathobiology of pheochromocytoma and extra-adrenal paraganglioma …