The role of short-chain fatty acids in immunity, inflammation and metabolism

Y Yao, X Cai, W Fei, Y Ye, M Zhao… - Critical reviews in food …, 2022 - Taylor & Francis
Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6,
which are important metabolites of gut microbiome. Existing research shows that SCFAs …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in cancer development and prevention

R Mirzaei, A Afaghi, S Babakhani, MR Sohrabi… - Biomedicine & …, 2021 - Elsevier
Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …

Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

H Zeng, S Umar, B Rust, D Lazarova… - International journal of …, 2019 - mdpi.com
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …

Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing

CM van der Beek, CHC Dejong, FJ Troost… - Nutrition …, 2017 - academic.oup.com
Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by
microbial fermentation of undigested food substances are believed to play a beneficial role …

[HTML][HTML] Inhibition of histone deacetylase activity by butyrate

JR Davie - The Journal of nutrition, 2003 - Elsevier
This article reviews the effects of the short-chain fatty acid butyrate on histone deacetylase
(HDAC) activity. Sodium butyrate has multiple effects on cultured mammalian cells that …

[HTML][HTML] Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention

H Zeng, DL Lazarova, M Bordonaro - World journal of …, 2014 - ncbi.nlm.nih.gov
Many epidemiological and experimental studies have suggested that dietary fiber plays an
important role in colon cancer prevention. These findings may relate to the ability of fiber to …

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase

MC Myzak, PA Karplus, FL Chung, RH Dashwood - Cancer research, 2004 - AACR
Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a
potent inducer of phase 2 detoxification enzymes and inhibits tumorigenesis in animal …

Impact of dietary fatty acids on metabolic activity and host intestinal microbiota composition in C57BL/6J mice

E Patterson, RM O'Doherty, EF Murphy… - British Journal of …, 2014 - cambridge.org
Different dietary fat and energy subtypes have an impact on both the metabolic health and
the intestinal microbiota population of the host. The present study assessed the impact of …

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer

K Kim, O Kwon, TY Ryu, CR Jung… - Molecular …, 2019 - spandidos-publications.com
Short-chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived
from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs …

Potato starch: a review of physicochemical, functional and nutritional properties

JH Dupuis, Q Liu - American Journal of Potato Research, 2019 - Springer
With a rapid increase in type-2 diabetes mellitus (T2DM) throughout the world in recent
years, it has also become a major human health issue. Today, more than one third of the …