Two-photon light-sheet microscopy (2P-SPIM) provides a unique combination of advantages
for fast and deep fluorescence imaging in live tissues. Detecting coherent signals such as …

A profound remodeling of the extracellular matrix occurs in many epithelial cancers. In
ovarian cancer, the minor collagen isoform of Col III becomes upregulated in invasive …

Fast imaging of molecular changes under high-resolution and label-free conditions are
essential for understanding in-vivo processes, however, current techniques are not able to …

Laser scanning microscopy using high-peak-power ultrashort near infrared light pulses can
visualize biological microstructures by utilizing non-linear optical processes, such as multi …

Polarization-resolved second harmonic generation (P-SHG) microscopy is an efficient
imaging modality for in situ observation of biopolymers structure in tissues, providing …

Second Harmonic Generation (SHG) microscopy coupled with polarization analysis has
great potential for use in tissue characterization, as molecular and supramolecular structural …

Conventional second harmonic generation (SHG) microscopy might not clearly reveal the
structure of complex samples if the interference between all scatterers in the focal volume …

We show that the canonical single frequency sarcomeric SHG intensity pattern (SHG-IP) of
control muscles is converted to double frequency sarcomeric SHG-IP in preserved mdx …

We present a theoretical simulation of the sarcomeric SHG intensity pattern (SHG-IP) that
takes into account myofibrillar misalignment that is experimentally observed in SHG images …

Light sheet microscopy (LSM) has emerged as one of most profound three dimensional (3D)
imaging tools in the life sciences over the last decade. However, LSM is currently performed …