The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

Covering: 2005 to 2007 Natural product and natural product-derived compounds that are
being evaluated in clinical trials or are in registration (as at 31st December 2007) have been …

Pompe's disease, glycogen-storage disease type II, and acid maltase deficiency are
alternative names for the same metabolic disorder. It is a pan-ethnic autosomal recessive …

A recently proposed therapeutic approach for lysosomal storage disorders (LSDs) relies
upon the ability of transcription factor EB (TFEB) to stimulate autophagy and induce …

Lysosomal storage disorders (LSDs) are a group of inborn metabolic diseases caused by
mutations in genes that encode proteins involved in different lysosomal functions, in most …

Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date
and are ideally positioned to take advantage of our increasing understanding of …

Lysosomal storage diseases (LSDs) are a group of genetic disorders due to defects in any
aspect of lysosomal biology. During the past two decades, different approaches have been …

Lysosomal enzymes are responsible for the degradation of a wide variety of glycolipids,
oligosaccharides, proteins, and glycoproteins. Inherited mutations in the genes that encode …

Many human diseases result from mutations in specific genes. Once translated, the resulting
aberrant proteins may be functionally competent and produced at near-normal levels …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …